Entry Detail

General Information

Database ID: LDA0000089
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXC13-AS
Full Name:HOXC13 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXC-AS5
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53935328End Site(bp):53939643
External Links:
Ensembl ID:ENSG00000249641
Ensembl Transcript ID:N/A
Entrez Gene:100874366.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5520D000077195
Disease Name:head and neck squamous cell carcinomaSquamous Cell Carcinoma of Head and Neck
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck.The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
Alias:carcinoma of the head and neck//squamous cell carcinoma of the head and neck//squamous cell carcinomas of head and neckSquamous Cell Carcinoma of Head and Neck//Head And Neck Squamous Cell Carcinomas//Squamous Cell Carcinoma, Head And Neck//Squamous Cell Carcinoma of the Head and Neck//Head and Neck Squamous Cell Carcinoma//HNSCC//Carcinoma, Squamous Cell of Head and Neck//Squamous Cell Carcinoma of the Larynx//Laryngeal Squamous Cell Carcinoma//Squamous Cell Carcinoma of Larynx//Squamous Cell Carcinoma of the Nasal Cavity//Oral Tongue Squamous Cell Carcinoma//Hypopharyngeal Squamous Cell Carcinoma//Oral Squamous Cell Carcinoma//Oral Cavity Squamous Cell Carcinoma//Oral Squamous Cell Carcinomas//Squamous Cell Carcinoma of the Mouth//Oropharyngeal Squamous Cell Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:632   
More Information
Causal ncRNA Number:464
Network:
Top Causal ncRNAs:
XIST  (Score: 1)
CYTOR  (Score: 1)
hsa_circ_0001971  (Score: 1)
MALAT1  (Score: 1)
GAS5  (Score: 1)
HOXA11-AS  (Score: 1)
NORAD  (Score: 1)
MEG3  (Score: 1)
NEAT1  (Score: 1)
CYTOR  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32763778
Disease Name:Squamous Cell Carcinoma of Head and Neck
Sample:OSCC tissues and cell lines
Dysfunction Pattern:regulation[ miR-378g/HOXC13 axis]
Validated Method:Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//EdU Staining//Transwell Assay
Description: In this study, GEPIA indicated that HOXC13-AS and its neighbor gene HOXC13 were upregulated in HNSC samples, and we consistently unveiled their upregulation in OSCC tissues and cell lines. In sum, our findings suggested that HOXC13-AS functioned as a ceRNA to accelerate the malignant behaviors of OSCC cells via miR-378g/HOXC13 axis, shedding a new light on the lncRNA-targeted treatment for OSCC.
Causality:Yes
Causal Description:Silencing HOXC13-AS abrogated OSCC cell proliferation, migration, and epithelial-to-mesenchymal transition (EMT).
Clinical-realted Application: