Entry Detail

General Information

Database ID: LDA0000100
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA11-AS
Full Name:HOXA11 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27185408End Site(bp):27189293
External Links:
Ensembl ID:ENSG00000240990
Ensembl Transcript ID:N/A
Entrez Gene:221883.0
NONCODE ID:N/A
RefSeq Accession:NR_002795.2

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Keloid  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8923
Disease Name:skin melanoma
Category:Disease Ontology
Type:Neoplasms
Define:A skin cancer that has_material_basis_in melanocytes.
Alias:cutaneous melanoma//malignant ear melanoma//malignant lip melanoma//malignant lower limb melanoma//malignant melanoma of ear and/or external auricular canal//malignant melanoma of skin of lower limb//malignant melanoma of skin of trunk except scrotum//malignant melanoma of skin of upper limb//malignant neck melanoma//malignant scalp melanoma//malignant trunk melanoma//malignant upper limb melanoma

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33564267
Disease Name:skin melanoma
Sample:melanoma tissues
Dysfunction Pattern:Interaction(miR-152-3p/ITGA9 Axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay
Description: HOXA11-AS and ITGA9 were up-regulated while miR-152-3p was down-regulated in melanoma. HOXA11-AS modulated proliferation, apoptosis, metastasis and EMT in melanoma cells by regulating miR-152-3p/ITGA9 axis in part.
Causality:Yes
Causal Description: Knockdown of HOXA11-AS refrained cell proliferation, metastasis and epithelial-mesenchymal transition (EMT) but induced apoptosis in melanoma cells.
Clinical-realted Application: