Entry Detail

General Information

Database ID: LDA0000101
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA11-AS
Full Name:HOXA11 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27185408End Site(bp):27189293
External Links:
Ensembl ID:ENSG00000240990
Ensembl Transcript ID:N/A
Entrez Gene:221883.0
NONCODE ID:N/A
RefSeq Accession:NR_002795.2

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Keloid  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003711
Disease Name:Demyelinating Diseases
Category:MeSH
Type:Nervous System Diseases
Define:Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Alias:Demyelinating Diseases//Demyelinating Disease//Demyelinating Disorders//Demyelinating Disorder//Demyelination//Demyelinations//Clinically Isolated Syndrome, CNS Demyelinating//Clinically Isolated CNS Demyelinating Syndrome

 

Disease Association Statistics

Total Associated ncRNA Number:54   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.731059)
HOXA11-AS  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Flow Cytometry//qRT-PCR//Tunel//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31878829
Disease Name:Demyelinating Diseases
Sample:keloid tissues
Dysfunction Pattern:Regulation[ miR-124-3p/TGFβR1 axis]
Validated Method:Flow Cytometry//qRT-PCR//Tunel//Western Blot
Description:We found that HOXA11-AS and TGFβR1 were significantly up-regulated, while miR-124-3p was down-regulated both in keloid tissues or fibroblasts than in normal skin tissues or fibroblasts. Taken together, our findings revealed that HOXA11-AS inhibits cell apoptosis and promotes angiogenesis through miR-124-3p/TGFβR1 axis, contributing to the progression of keloid formation, which might provide a novel target for keloid therapy.
Causality:Yes
Causal Description: Functionally, high expression of HOXA11-AS essentially inhibited cell apoptosis and promoted fibroblast-induced angiogenesis.
Clinical-realted Application: