Entry Detail

General Information

Database ID: LDA0000108
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA-AS2
Full Name:HOXA cluster antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA3as
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27121919End Site(bp):27128760
External Links:
Ensembl ID:ENSG00000253552
Ensembl Transcript ID:N/A
Entrez Gene:285943.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Glioma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3121D005706
Disease Name:gallbladder cancerGallbladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A biliary tract cancer that is located_in the gallbladder.Tumors or cancer of the gallbladder.
Alias:gallbladder Ca//gallbladder neoplasm//localized malignant gallbladder neoplasm//malignant neoplasm of gallbladder//malignant tumor of the gallbladder//malignant tumour of gallbladder//tumor of the gallbladderGallbladder Neoplasms//Gallbladder Neoplasm//Neoplasm, Gallbladder//Neoplasms, Gallbladder//Cancer of Gallbladder//Gallbladder Cancers//Gallbladder Cancer//Cancer, Gallbladder//Cancers, Gallbladder//Gall Bladder Cancer//Bladder Cancer, Gall//Bladder Cancers, Gall//Cancer, Gall Bladder//Cancers, Gall Bladder//Gall Bladder Cancers//Cancer of the Gallbladder

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:38
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.999893)
PVT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01410  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
RP11-147L13.8  (Score: 0.731059)
HOXA-AS2  (Score: 0.731059)
EPIC1  (Score: 0.731059)
FIRRE  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36299503
Disease Name:Gallbladder Neoplasms
Sample:gallbladder carcinoma tissues
Dysfunction Pattern:Interaction(miR-6867/Hippo )
Validated Method:Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay//Transwell Assay
Description:The expression of HOXA-AS2 in gallbladder carcinoma tissues was significantly higher than that in adjacent tissues (p < 0.05). Through software prediction and fluorescein reporter gene detection, it was found that HOXA-AS2 has a binding site with miR-6867, and the two are negatively correlated, that is, the expression of miR-6867 is enhanced after the expression of HOXA-AS2 is downregulated. And the 3'UTR of YAP1 protein in the Hippo signaling pathway binds to miR-6867. Therefore, HOXA-AS2 may affect the expression of YAP1 protein by regulating miR-6867, thereby inhibiting the Hippo signaling pathway and promoting the proliferation and metastasis of gallbladder cancer cells. HOXA-AS2 is abnormally expressed in gallbladder cancer cells.
Causality:Yes
Causal Description:Through cell proliferation and plate clone detection, it was found that silencing HOXA-AS2 inhibited cell proliferation and invasion.
Clinical-realted Application: