Entry Detail

General Information

Database ID: LDA0000111
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA-AS2
Full Name:HOXA cluster antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA3as
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27121919End Site(bp):27128760
External Links:
Ensembl ID:ENSG00000253552
Ensembl Transcript ID:N/A
Entrez Gene:285943.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Glioma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:687D018197
Disease Name:hepatoblastomaHepatoblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
Alias:Hepatoblastoma//Hepatoblastomas

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 0.731059)
LINC00205  (Score: 0.731059)
GAS5  (Score: 0.731059)
LUCAT1  (Score: 0.731059)
LINC01023  (Score: 0.731059)
circHMGCS1  (Score: 0.731059)
circSETD3  (Score: 0.731059)
hsa_circ_0000594  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MIR210HG  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33683826
Disease Name:Hepatoblastoma
Sample:HB tissues
Dysfunction Pattern:Interaction(ARID1B/HOXA-AS2/HOXA3 axis)
Validated Method:In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//Invasion Assay
Description:In our previous study, genome-wide analysis with a lncRNA microarray found that lncRNA HOXA-AS2 was up-regulated in HB. . In conclusion, HOXA-AS2 is significantly overexpressed in HB and the ARID1B/HOXA-AS2/HOXA3 axis plays a critical role in HB tumorigenesis and development.
Causality:Yes
Causal Description:Our data revealed knockdown of HOXA-AS2 increased cell apoptosis and inhibited cell proliferation, migration and invasion in HB. Up-regulation of HOXA-AS2 promoted HB malignant biological behaviours.
Clinical-realted Application: