Entry Detail

General Information

Database ID: LDA0000112
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA-AS2
Full Name:HOXA cluster antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA3as
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27121919End Site(bp):27128760
External Links:
Ensembl ID:ENSG00000253552
Ensembl Transcript ID:N/A
Entrez Gene:285943.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Glioma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:14004D017545
Disease Name:thoracic aortic aneurysmAortic Aneurysm, Thoracic
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An aortic aneurysm that is located_in the thoracic aorta.An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Alias:Aortic Aneurysm, Thoracic//Thoracic Aortic Aneurysms//Thoracic Aorta Aneurysm//Aneurysm, Thoracic Aortic//Aneurysm, Thoracic Aorta//Aorta Aneurysm, Thoracic//Thoracic Aorta Aneurysms//Thoracic Aortic Aneurysm

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
HOXA-AS2  (Score: 0.731059)
H19  (Score: 0.731059)
NEAT1  (Score: 0.731059)
HOXA-AS2  (Score: 0.731059)
H19  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Apoptosis Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:35730141
Disease Name:Aortic Aneurysm, Thoracic
Sample:VSMCs, TAA tissues
Dysfunction Pattern:Interaction(IGF2BP3/KIAA1522)
Validated Method:RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Apoptosis Assay//EdU Staining
Description: HOXA-AS2 was detected to have significantly high expression in TAA tissues and function as an oncogene to promote proliferation of VSMCs, while inhibiting cell apoptosis (Figure 1, **P < 0.01). HOXA-AS2 was unveiled to bind with miR-520d-3p (Figure 2, *P < 0.05, **P < 0.01) and further up-regulate KIAA1522 to facilitate the growth of VSMCs (Figure 3-4, *P < 0.05, **P < 0.01). HOXA-AS2 was also found to recruit IGF2BP3 to stabilize KIAA1522 mRNA (Figure 5, **P < 0.01).
Causality:Yes
Causal Description: HOXA-AS2 was detected to have significantly high expression in TAA tissues and function as an oncogene to promote proliferation of VSMCs, while inhibiting cell apoptosis (Figure 1, **P < 0.01).
Clinical-realted Application: