Entry Detail

General Information

Database ID: LDA0000142
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HEIH
Full Name:hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HCCAT2|LINC-HEIH|LINC00848|lncRNA-HEIH
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):180829954End Site(bp):180831618
External Links:
Ensembl ID:ENSG00000278970
Ensembl Transcript ID:N/A
Entrez Gene:100859930.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077277
Disease Name:Esophageal Squamous Cell Carcinoma
Category:MeSH
Type:Neoplasms
Define:A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.
Alias:Esophageal Squamous Cell Carcinoma//Oesophageal Squamous Cell Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:2730   
More Information
Causal ncRNA Number:360
Network:
Top Causal ncRNAs:
ciRS-7  (Score: 1)
ZNF667-AS1  (Score: 1)
SNHG6  (Score: 1)
ZNF667-AS1  (Score: 1)
BBOX1-AS1  (Score: 1)
SNHG6  (Score: 1)
CASC9  (Score: 1)
ciRS-7  (Score: 1)
CASC9  (Score: 1)
BBOX1-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32449803
Disease Name:Esophageal Squamous Cell Carcinoma
Sample:ESCC tissues and cell lines
Dysfunction Pattern:regulation[miR-4458/PBX3]
Validated Method:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:HEIH was confirmed to be upregulated in both ESCC tissues and cell lines. The present study clarified that HEIH regulated ESCC progression by suppressing miR-4458 and upregulating PBX3.
Causality:Yes
Causal Description:Functionally, we noticed that depletion of HEIH restrained ESCC cell viability, and invasion capability.
Clinical-realted Application:

[2] PubMed ID:32729661
Disease Name:Esophageal Squamous Cell Carcinoma
Sample:ESCC tissues
Dysfunction Pattern:regulation[TP53]
Validated Method:qRT-PCR
Description:In the present study, an obvious up-regulation of lncRNA-HEIH was observed in ESCC compared to the adjacent normal tissues.We further found that lncRNA-HEIH was associated with enhancer of zeste homolog 2 (EZH2) and that this association led to the repression of TP53.
Causality:No
Causal Description:
Clinical-realted Application:Meanwhile, patients with high expression of lncRNA-HEIH have significantly poorer prognosis than those with low expression.