Entry Detail

General Information

Database ID: LDA0000145
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HEIH
Full Name:hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HCCAT2|LINC-HEIH|LINC00848|lncRNA-HEIH
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):180829954End Site(bp):180831618
External Links:
Ensembl ID:ENSG00000278970
Ensembl Transcript ID:N/A
Entrez Gene:100859930.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1107
Disease Name:esophageal carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Alias:cancer of esophagus//cancer of oesophagus//carcinoma of esophagus//carcinoma of oesophagus

 

Disease Association Statistics

Total Associated ncRNA Number:26   
More Information
Causal ncRNA Number:26
Network:
Top Causal ncRNAs:
LOC441178  (Score: 0.985791)
LOC441178  (Score: 0.985791)
MIR205HG  (Score: 0.731059)
hsa_circ_0043898  (Score: 0.731059)
AK058003  (Score: 0.731059)
CASC11  (Score: 0.731059)
MANCR  (Score: 0.731059)
PVT1  (Score: 0.731059)
circPDE3B  (Score: 0.731059)
circATIC  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//ISH//FISH//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33223519
Disease Name:esophageal carcinoma
Sample:EC tissues
Dysfunction Pattern:regulation[upregulating microRNA-185 and downregulating KLK5]
Validated Method:RNA Pull-Down//Western Blot//ISH//qRT-PCR//FISH//Luciferase Report Assay//H&E Staining//IHC//EdU Staining//Transwell Assay
Description: Results from this study indicated that HEIH and KLK5 were elevated and miR-185 was declined in EC. Collectively, we reveal that HEIH depletion dampens EC progression by upregulating miR-185 and downregulating KLK5, which provides novel treatments for EC.
Causality:Yes
Causal Description:Depleting HEIH or restoring miR-185 suppressed the malignant phenotypes of EC cells, and delayed tumor growth in EC mice.
Clinical-realted Application:High HEIH and KLK5 indicated worse prognosis and high miR-185 suggested better prognosis of EC patients.