Entry Detail

General Information

Database ID: LDA0000146
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HEIH
Full Name:hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HCCAT2|LINC-HEIH|LINC00848|lncRNA-HEIH
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):180829954End Site(bp):180831618
External Links:
Ensembl ID:ENSG00000278970
Ensembl Transcript ID:N/A
Entrez Gene:100859930.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4928D018281
Disease Name:intrahepatic cholangiocarcinomaCholangiocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree.A malignant tumor arising from the epithelium of the BILE DUCTS.
Alias:Intrahepatic bile duct carcinoma//peripheral CholangiocarcinomaCholangiocarcinoma//Cholangiocarcinomas//Cholangiocellular Carcinoma//Carcinoma, Cholangiocellular//Carcinomas, Cholangiocellular//Cholangiocellular Carcinomas//Extrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Extrahepatic//Cholangiocarcinomas, Extrahepatic//Extrahepatic Cholangiocarcinomas//Intrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Intrahepatic//Cholangiocarcinomas, Intrahepatic//Intrahepatic Cholangiocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:144
Network:
Top Causal ncRNAs:
NNT-AS1  (Score: 0.999893)
NNT-AS1  (Score: 0.999893)
SNHG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TTN-AS1  (Score: 0.985791)
SNHG1  (Score: 0.985791)
AGAP2-AS1  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:32062383
Disease Name:Cholangiocarcinoma
Sample:CHOL tissues and cells
Dysfunction Pattern:regulation[miR-98-5p/HECTD4]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP
Description:According to the results, HEIH expression was up-regulated in CHOL tissues and cells. In conclusion, HEIH promoted CHOL tumorigenesis and progression by miR-98-5p/HECTD4 axis, which opens up a new insight for CHOL therapeutics.
Causality:Yes
Causal Description: Functionally, knockdown of HEIH attenuated cell proliferation, migration and invasion.
Clinical-realted Application: