Entry Detail

General Information

Database ID: LDA0000150
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HDAC1
Full Name:histone deacetylase 1
Category:LncRNA
Species:Homo sapiens
Synonyms:GON-10|HD1|KDAC1|RPD3|RPD3L1
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):32292083End Site(bp):32333626
External Links:
Ensembl ID:ENSG00000116478
Ensembl Transcript ID:N/A
Entrez Gene:3065.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Multiple Myeloma  (Score: 0.731059)
Multiple Myeloma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9538D009101
Disease Name:multiple myelomaMultiple Myeloma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid neoplasm that is located_in the plasma cells in bone marrow.A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Alias:Multiple Myeloma//Multiple Myelomas//Myelomas, Multiple//Myeloma, Multiple//Myeloma, Plasma-Cell//Myeloma, Plasma Cell//Myelomas, Plasma-Cell//Plasma-Cell Myeloma//Plasma-Cell Myelomas//Myelomatosis//Myelomatoses//Plasma Cell Myeloma//Cell Myeloma, Plasma//Cell Myelomas, Plasma//Myelomas, Plasma Cell//Plasma Cell Myelomas//Kahler Disease//Disease, Kahler//Myeloma-Multiple//Myeloma Multiple//Myeloma-Multiples

 

Disease Association Statistics

Total Associated ncRNA Number:180   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
CDKN2B-AS1  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
hsa_circ_0007841  (Score: 0.985791)
lnc-TCF7  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34738621
Disease Name:Multiple Myeloma
Sample:myeloma cells
Dysfunction Pattern:Interaction(Slug)
Validated Method:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay
Description: In the present study, the expression of class I HDACs in myeloma cells and tissues was evaluated. Mechanistically, the results revealed that HDAC1 regulated the mRNA stability of Slug, while it had no effect on its transcription or nuclear export.
Causality:Yes
Causal Description:Targeted inhibition of HDAC1 suppressed the migration of myeloma cells. Of the assessed transcription factors, small interfering (si)‑HDAC1 decreased the expression of Slug.
Clinical-realted Application: