LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0000152
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

HCP5

Full Name:

HLA complex P5

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

6S2650E|D6S2650E|P5-1

Chromosome:

Strand:

Coordinate:

Start Site(bp):

31463180

End Site(bp):

31465809

External Links:

Ensembl ID:	ENSG00000237105
Ensembl Transcript ID:	N/A
Entrez Gene:	10866.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

48 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Stomach Neoplasms (Score: 1)

Osteosarcoma (Score: 0.999893)

Colorectal Neoplasms (Score: 0.985791)

Carcinoma, Renal Cell (Score: 0.985791)

Squamous Cell Carcinoma of Head and Neck (Score: 0.985791)

Pancreatic Neoplasms (Score: 0.985791)

Squamous Cell Carcinoma of Head and Neck (Score: 0.985791)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:0080522	D065646
Disease Name:	thyroid gland anaplastic carcinoma	Thyroid Carcinoma, Anaplastic
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A thyroid gland carcinoma that is composed of undifferentiated cells.	An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.
Alias:	anaplastic thyroid carcinoma	Thyroid Carcinoma, Anaplastic//Anaplastic Thyroid Carcinoma//Anaplastic Thyroid Carcinomas//Carcinoma, Anaplastic Thyroid//Carcinomas, Anaplastic Thyroid//Thyroid Carcinomas, Anaplastic//Thyroid Cancer, Anaplastic//Anaplastic Thyroid Cancer//Anaplastic Thyroid Cancers//Cancer, Anaplastic Thyroid//Cancers, Anaplastic Thyroid//Thyroid Cancers, Anaplastic

Disease Association Statistics

Total Associated ncRNA Number:

16 More Information

Causal ncRNA Number:

Network:

Top Causal ncRNAs:

UCA1 (Score: 0.985791)

HOTAIRM1 (Score: 0.731059)

HCP5 (Score: 0.731059)

H19 (Score: 0.731059)

AFAP-AS1 (Score: 0.731059)

MANCR (Score: 0.731059)

HOTAIRM1 (Score: 0.731059)

HCP5 (Score: 0.731059)

H19 (Score: 0.731059)

More Information

Evidence Support

Strong Evidence:	qRT-PCR//MTT//RIP
Weak Evidence:

Reference

[1] PubMed ID:	31102936
Disease Name:	Thyroid Carcinoma, Anaplastic
Sample:	ATC tissues
Dysfunction Pattern:	Interaction[sponging miR-128-3p ]
Validated Method:	qRT-PCR//MTT//RIP
Description:	Besides, HCP5 expression level was increased in ATC tissues when compared with adjacent normal tissues. MiR-128-3p was predicted to be a target gene of HCP5. The expression level of miR-128-3p was significantly decreased in ATC cells and tissues, as compared to Nthy-ori 3-1 cells and adjacent normal tissues, respectively. MiR-128-3p overexpression reduced ATC cell viability, and induced cell apoptosis. HCP5 directly bound to miR-128-3p and regulated the expression of miR-128-3p in ARO and SW1736 cells. Furthermore, the effects of HCP5 knockdown on ATC cell viability and apoptosis were attenuated by the inhibitor of miR-128-3p. These findings suggested that knockdown of HCP5 exerted anti-tumor effect via sponging miR-128-3p in ATC, which might provide a potential approach for the treatment of ATC.
Causality:	Yes
Causal Description:	Knockdown of HCP5 reduced cell viability, while elevated apoptotic rate and caspase-3/7 activity in ARO and SW1736 cells.
Clinical-realted Application:

LncRNADisease v3.0

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