Entry Detail

General Information

Database ID: LDA0000170
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HCP5
Full Name:HLA complex P5
Category:LncRNA
Species:Homo sapiens
Synonyms:6S2650E|D6S2650E|P5-1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):31463180End Site(bp):31465809
External Links:
Ensembl ID:ENSG00000237105
Ensembl Transcript ID:N/A
Entrez Gene:10866.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:48   
More Information
Causal Disease Number:48
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Osteosarcoma  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4481D065631
Disease Name:allergic rhinitisRhinitis, Allergic
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.An inflammation of the NASAL MUCOSA triggered by ALLERGENS.
Alias:Non-seasonal allergic rhinitis//Perenial allergic rhinitis//atopic rhinitis//hay fever//pollenosis//seasonal allergic rhinitisRhinitis, Allergic//Allergic Rhinitides//Rhinitides, Allergic//Allergic Rhinitis

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0067835  (Score: 0.731059)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transection//qRT-PCR//CCK8//Flow Cytometry//Luciferase Report Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35122570
Disease Name:Rhinitis, Allergic
Sample:PBMCs, CD4+ T cells, Tregs, and nasal tissues of AR patients
Dysfunction Pattern:Interaction(miR-16/ATXN2L axis)
Validated Method:Western Blot//Transection//qRT-PCR//Flow Cytometry//CCK8//Luciferase Report Assay//ELISA
Description: lncRNA HCP5 expression dramatically downregulated in PBMCs, CD4+ T cells, Tregs, and nasal tissues of AR patients, as well as in IL-13-treated NECs.HCP5 promoted Tregs differentiation and proliferation via targeting miR-16/ATXN2L axis. Additionally, HCP5 inhibited IL-13-induced GM-CSF, eotaxin, and MUC5AC production in NECs. HCP5 sponged miR-16 and negatively regulated its expression, and miR-16 targeted ATXN2L and inhibition of miR-16 suppressed IL-13-induced GM-CSF, eotaxin, and MUC5AC expression. HCP5/miR-16/ATXN2L axis mediated Tregs proliferation and functions in AR. Besides, the regulation of IL-13-induced dysfunction of NECs by lncRNA HCP5 depended on miR-16/ATXN2L in the inflammatory response of AR.
Causality:Yes
Causal Description:HCP5 promoted Tregs differentiation and proliferation via targeting miR-16/ATXN2L axis.
Clinical-realted Application: