Entry Detail

General Information

Database ID: LDA0000174
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HCP5
Full Name:HLA complex P5
Category:LncRNA
Species:Homo sapiens
Synonyms:6S2650E|D6S2650E|P5-1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):31463180End Site(bp):31465809
External Links:
Ensembl ID:ENSG00000237105
Ensembl Transcript ID:N/A
Entrez Gene:10866.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:48   
More Information
Causal Disease Number:48
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Osteosarcoma  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4159D012878
Disease Name:skin cancerSkin Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.Tumors or cancer of the SKIN.
Alias:CA - skin cancer//malignant neoplasm of skin//melanoma and Non-melanoma skin cancerSkin Neoplasms//Neoplasms, Skin//Neoplasm, Skin//Skin Neoplasm//Cancer of Skin//Skin Cancers//Cancer of the Skin//Skin Cancer//Cancer, Skin//Cancers, Skin

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
PICSAR  (Score: 0.985791)
PICSAR  (Score: 0.985791)
circSEC24A  (Score: 0.731059)
circLARP1B  (Score: 0.731059)
PRECSIT  (Score: 0.731059)
SCARNA2  (Score: 0.731059)
H19  (Score: 0.731059)
EZR‑AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Flow Cytometry//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34195851
Disease Name:Skin Neoplasms
Sample:CSCC cells
Dysfunction Pattern:Regulation(STAT3/VEGFR2 pathway)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Tunel//CCK8//qRT-PCR//Flow Cytometry//Microarray//IHC//Transwell Assay
Description:In conclusion, HCP5 may competitively bind to miR‑138‑5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway.
Causality:Yes
Causal Description:In conclusion, HCP5 may competitively bind to miR?138?5p to regulate EZH2 in CSCC cells, promoting autophagy and reducing apoptosis through the STAT3/VEGFR2 pathway.
Clinical-realted Application: