Entry Detail

General Information

Database ID: LDA0000175
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HCP5
Full Name:HLA complex P5
Category:LncRNA
Species:Homo sapiens
Synonyms:6S2650E|D6S2650E|P5-1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):31463180End Site(bp):31465809
External Links:
Ensembl ID:ENSG00000237105
Ensembl Transcript ID:N/A
Entrez Gene:10866.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:48   
More Information
Causal Disease Number:48
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Osteosarcoma  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8923
Disease Name:skin melanoma
Category:Disease Ontology
Type:Neoplasms
Define:A skin cancer that has_material_basis_in melanocytes.
Alias:cutaneous melanoma//malignant ear melanoma//malignant lip melanoma//malignant lower limb melanoma//malignant melanoma of ear and/or external auricular canal//malignant melanoma of skin of lower limb//malignant melanoma of skin of trunk except scrotum//malignant melanoma of skin of upper limb//malignant neck melanoma//malignant scalp melanoma//malignant trunk melanoma//malignant upper limb melanoma

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31496735
Disease Name:skin melanoma
Sample:SKCM tissue
Dysfunction Pattern:Interaction[sponging miR-12]
Validated Method:Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Invasion Assay//Transwell Assay
Description:HCP5 level was decreased in SKCM tissue specimens compared to noncancerous counterparts.HCP5 overexpression decreased SKCM cell malignancy in vitro by upregulating RARRES3, possibly via sponging miR-1286.
Causality:Yes
Causal Description:HCP5 overexpression significantly reduced the malignancy of primary SKCM cells in vitro.
Clinical-realted Application:Low expression of HCP5 was associated with SKCM patients' poor overall survival and disease progression.