Entry Detail

General Information

Database ID: LDA0000184
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HIF1A-AS2
Full Name:HIF1A antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:3'aHIF-1A|aHIF
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):61747039End Site(bp):61749089
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:100750247.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:28   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Carcinoma, Renal Cell  (Score: 0.985791)
Carcinoma, Ovarian Epithelial  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Carcinoma, Ovarian Epithelial  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.959542)
Triple Negative Breast Neoplasms  (Score: 0.959542)
Adenocarcinoma of Lung  (Score: 0.731059)
Small Cell Lung Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D055752
Disease Name:Small Cell Lung Carcinoma
Category:MeSH
Type:Neoplasms
Define:A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Alias:Small Cell Lung Carcinoma//Small Cell Lung Cancer//Oat Cell Lung Cancer//Small Cell Cancer Of The Lung//Carcinoma, Small Cell Lung//Oat Cell Carcinoma of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
circPVT1  (Score: 0.731059)
KCNQ1OT1  (Score: 0.731059)
LUADT1  (Score: 0.731059)
LINC01555  (Score: 0.731059)
LINC01116  (Score: 0.731059)
CASC11  (Score: 0.731059)
ZFPM2-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
NEF  (Score: 0.731059)
HIF1A-AS2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Cell Apoptosis Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:34378101
Disease Name:Small Cell Lung Carcinoma
Sample:SCLC cells
Dysfunction Pattern:Regulation
Validated Method:qRT-PCR//Transfection//Cell Apoptosis Assay//Western Blot
Description:The levels of HIF-1α and Beclin-1 were decreased in both cell lines by knockdown of HIF1A-AS2. MRP1 expression was decrease in H69AR cells. In addition, CoCl2-induced hypoxic environment decreased in doxorubicin sensitivity of H69 cells, and knockdown of HIF1A-AS2 reversed this effect of hypoxia. Knockdown of HIF1A-AS2 increased drug sensitivity of SCLC cells in relation to autophagy.
Causality:Yes
Causal Description:Knockdown of HIF1A-AS2 increased doxorubicin sensitivity of SCLC cells and decreased autophagy. Knockdown of HIF1A-AS2 has also affected the expression of several genes that will increase drug sensitivity and inhibit autophagy in both cell lines.
Clinical-realted Application: