Entry Detail

General Information

Database ID: LDA0000202
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIR
Full Name:HOX transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53962308End Site(bp):53974956
External Links:
Ensembl ID:ENSG00000228630
Ensembl Transcript ID:N/A
Entrez Gene:100124700.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:110   
More Information
Causal Disease Number:68
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080208D065626
Disease Name:non-alcoholic fatty liver diseaseNon-alcoholic Fatty Liver Disease
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A fatty liver disease characterized by the storing of excess fat in liver cells which is not caused by heavy alcohol use.Fatty liver finding without excessive ALCOHOL CONSUMPTION.
Alias:NAFLDNon-alcoholic Fatty Liver Disease//Non alcoholic Fatty Liver Disease//NAFLD//Nonalcoholic Fatty Liver Disease//Fatty Liver, Nonalcoholic//Fatty Livers, Nonalcoholic//Liver, Nonalcoholic Fatty//Livers, Nonalcoholic Fatty//Nonalcoholic Fatty Liver//Nonalcoholic Fatty Livers//Nonalcoholic Steatohepatitis//Nonalcoholic Steatohepatitides//Steatohepatitides, Nonalcoholic//Steatohepatitis, Nonalcoholic

 

Disease Association Statistics

Total Associated ncRNA Number:82   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
Gas5  (Score: 0.985791)
Gas5  (Score: 0.985791)
RMRP  (Score: 0.731059)
hsa_circ_0057558  (Score: 0.731059)
Pvt1  (Score: 0.731059)
PTK2  (Score: 0.731059)
hsa_circ_0001805  (Score: 0.731059)
Platr4  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Oil Red O Staining
Weak Evidence:

 

Reference

[1] PubMed ID:34774989
Disease Name:Non-alcoholic Fatty Liver Disease
Sample:NAFLD tissues
Dysfunction Pattern:Interaction(miR-130b-3p/ROCK1 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Oil Red O Staining
Description: The level of HOTAIR was upregulated in NAFLD. Meanwhile, HOTAIR bound with miR-130b-3p, and ROCK1 was identified to be the direct target of miR-130b-3p. Moreover, miR-130b-3p mimics-caused lipid accumulation decrease was reversed by pcDNA3.1-ROCK1.
Causality:Yes
Causal Description:Downregulation of HOTAIR reversed lipid accumulation in FFA-treated HepG2 cells and primary hepatocytes.
Clinical-realted Application: