Entry Detail


General Information

Database ID: LDA0000204
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIR
Full Name:HOX transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53962308End Site(bp):53974956
External Links:
Ensembl ID:ENSG00000228630
Ensembl Transcript ID:N/A
Entrez Gene:100124700.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:110   
More Information
Causal Disease Number:68
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3083D029424
Disease Name:chronic obstructive pulmonary diseasePulmonary Disease, Chronic Obstructive
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Alias:COLD//COPD//chronic obstructive airway disease//chronic obstructive lung diseasePulmonary Disease, Chronic Obstructive//Chronic Obstructive Lung Disease//Chronic Obstructive Pulmonary Diseases//COAD//COPD//Chronic Obstructive Airway Disease//Chronic Obstructive Pulmonary Disease//Airflow Obstruction, Chronic//Airflow Obstructions, Chronic//Chronic Airflow Obstructions//Chronic Airflow Obstruction

 

Disease Association Statistics

Total Associated ncRNA Number:76   
More Information
Causal ncRNA Number:26
Network:
Top Causal ncRNAs:
TUG1  (Score: 0.985791)
TUG1  (Score: 0.985791)
RUBCNL  (Score: 0.731059)
IL6-AS1  (Score: 0.731059)
GAS5  (Score: 0.731059)
MALAT1  (Score: 0.731059)
LINC00987  (Score: 0.731059)
CASC2  (Score: 0.731059)
hsa_circ_0006872  (Score: 0.731059)
circBPTF  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36527094
Disease Name:Pulmonary Disease, Chronic Obstructive
Sample:COPD patient lungs and CSE-induced HPVEC
Dysfunction Pattern:Interaction(DNMT1)
Validated Method:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Microarray//Cell Proliferation Assay
Description: The expression levels of the HOTAIR were up-regulated in COPD patient lungs and CSE-induced HPVEC. HPVEC apoptosis with down-regulated Bcl-2 expression, increased promoter methylation, DNMT1, Bax and Cleaved-caspase 3 expression was found in emphysema mouse model and CSE-induced HPVEC. DNMT1 was a target of HOTAIR and had a positive correlation with HOTAIR.
Causality:Yes
Causal Description: Knockdown HOTAIR can attenuate cell apoptosis and emphysema via DNMT1 mediated hypermethylation of Bcl-2 promoter in mice. In vitro, HOTAIR can aggravate the apoptosis of CSE-exposed HPVEC.
Clinical-realted Application: