LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0000206
Species:	Homo sapiens
Confidence Score:	0.985791
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

HOTAIR

Full Name:

HOX transcript antisense RNA

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072

Chromosome:

Strand:

Coordinate:

Start Site(bp):

53962308

End Site(bp):

53974956

External Links:

Ensembl ID:	ENSG00000228630
Ensembl Transcript ID:	N/A
Entrez Gene:	100124700.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

110 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Carcinoma, Hepatocellular (Score: 1)

Breast Neoplasms (Score: 1)

Stomach Neoplasms (Score: 1)

Breast Neoplasms (Score: 1)

Stomach Neoplasms (Score: 1)

Carcinoma, Non-Small-Cell Lung (Score: 1)

Colorectal Neoplasms (Score: 1)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:9261	C538339
Disease Name:	nasopharynx carcinoma	Nasopharyngeal carcinoma
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.	A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:	Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

Disease Association Statistics

Total Associated ncRNA Number:

260 More Information

Causal ncRNA Number:

244

Network:

Top Causal ncRNAs:

ZFAS1 (Score: 1)

DANCR (Score: 0.999893)

XIST (Score: 0.999893)

DANCR (Score: 0.999893)

circZNF609 (Score: 0.985791)

hsa_circ_0008450 (Score: 0.985791)

PVT1 (Score: 0.985791)

circZNF609 (Score: 0.985791)

More Information

Evidence Support

Strong Evidence:	In Vivo Experiment//Western Blot//Transwell Assay//Transfection//Wound Healing Assay//Colony Formation Assay//Flow Cytometry//qRT-PCR//RIP//MTT//migration assay//Luciferase Report Assay//H&E Staining//cell invasion assay//IHC//ChIP
Weak Evidence:

Reference

[1] PubMed ID:	33965547
Disease Name:	Nasopharyngeal carcinoma
Sample:	NPC tissues and cells
Dysfunction Pattern:	Expression [highly expressed]
Validated Method:	In Vivo Experiment//IHC//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//migration assay//H&E Staining//cell invasion assay//Colony Formation Assay//ChIP
Description:	LncRNA HOTAIR and EZH2 were highly expressed in NPC, and E-cadherin was lowly expressed. HOTAIR recruited histone methylase EZH2 to mediate trimethylation of H3K27 and regulated E-cadherin expression.
Causality:	Yes
Causal Description:	Down-regulation of HOTAIR or EZH2 inhibited NPC cell progression and tumor growth.
Clinical-realted Application:

[2] PubMed ID:	30314699
Disease Name:	Nasopharyngeal carcinoma
Sample:	NPC tissues and cells
Dysfunction Pattern:	Regulation[HOTAIR/miR-101/COX-2 axis]
Validated Method:	Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Description:	HOTAIR was upregulated in NPC tissues and cells. Here, we highlight the importance of HOTAIR/miR-101/COX-2 axis in progression of nasopharyngeal carcinoma cells.
Causality:	No
Causal Description:
Clinical-realted Application:

LncRNADisease v3.0

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