Entry Detail

General Information

Database ID: LDA0000214
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIR
Full Name:HOX transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53962308End Site(bp):53974956
External Links:
Ensembl ID:ENSG00000228630
Ensembl Transcript ID:N/A
Entrez Gene:100124700.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:110   
More Information
Causal Disease Number:68
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003928
Disease Name:Diabetic Nephropathies
Category:MeSH
Type:Urogenital Diseases
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Alias:Diabetic Nephropathies//Nephropathies, Diabetic//Nephropathy, Diabetic//Diabetic Nephropathy//Diabetic Kidney Disease//Diabetic Kidney Diseases//Kidney Disease, Diabetic//Kidney Diseases, Diabetic//Diabetic Glomerulosclerosis//Glomerulosclerosis, Diabetic//Intracapillary Glomerulosclerosis//Nodular Glomerulosclerosis//Glomerulosclerosis, Nodular//Kimmelstiel-Wilson Syndrome//Kimmelstiel Wilson Syndrome//Syndrome, Kimmelstiel-Wilson//Kimmelstiel-Wilson Disease//Kimmelstiel Wilson Disease

 

Disease Association Statistics

Total Associated ncRNA Number:72   
More Information
Causal ncRNA Number:58
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999998)
MALAT1  (Score: 0.999998)
MIAT  (Score: 0.985791)
MIAT  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
CASC2  (Score: 0.731059)
CASC2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:35193668
Disease Name:Diabetic Nephropathies
Sample:HMC
Dysfunction Pattern:Interaction( miR-147a/WNT2B axis)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining
Description: LncRNA HOTAIR could serve as a sponge of miR-147a. The inhibition effect of lncRNA HOTAIR silencing on the biological functions of HG-induced HMC could be reversed by miR-147a inhibitor. WNT2B was targeted by miR-147a, and its overexpression also overturned the suppressive effect of miR-147a on the proliferation, fibrosis, and oxidative stress of HG-induced HMC.
Causality:Yes
Causal Description:Our data showed that lncRNA HOTAIR knockdown could inhibit the proliferation, fibrosis, and oxidative stress in HG-induced HMC.
Clinical-realted Application: