Entry Detail

General Information

Database ID: LDA0000223
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HIPK3
Full Name:homeodomain interacting protein kinase 3
Category:LncRNA
Species:Homo sapiens
Synonyms:DYRK6|FIST3|PKY|YAK1
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):33256672End Site(bp):33357023
External Links:
Ensembl ID:ENSG00000110422
Ensembl Transcript ID:N/A
Entrez Gene:10114.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.731059)
Acute Kidney Injury  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Acute Kidney Injury  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D058186
Disease Name:Acute Kidney Injury
Category:MeSH
Type:Urogenital Diseases
Define:Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Alias:Acute Kidney Injury//Acute Kidney Injuries//Kidney Injuries, Acute//Kidney Injury, Acute//Acute Renal Injury//Acute Renal Injuries//Renal Injuries, Acute//Renal Injury, Acute//Renal Insufficiency, Acute//Acute Renal Insufficiencies//Renal Insufficiencies, Acute//Acute Renal Insufficiency//Kidney Insufficiency, Acute//Acute Kidney Insufficiencies//Kidney Insufficiencies, Acute//Acute Kidney Insufficiency//Kidney Failure, Acute//Acute Kidney Failures//Kidney Failures, Acute//Acute Renal Failure//Acute Renal Failures//Renal Failures, Acute//Renal Failure, Acute//Acute Kidney Failure

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PVT1  (Score: 0.731059)
Kcnq1ot1  (Score: 0.731059)
H19  (Score: 0.731059)
CASC2  (Score: 0.731059)
SNHG14  (Score: 0.731059)
hsa_circ_0020339  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35148669
Disease Name:Acute Kidney Injury
Sample:septic AKI patients and LPS-triggered HK2 cells
Dysfunction Pattern:Interaction( microRNA-338/forkhead box A1 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA
Description: The results displayed that circHIPK3 expression was enhanced in septic AKI patients and LPS-triggered HK2 cells. Furthermore, circHIPK3 functioned as a molecular sponge for miR-338, and forkhead box A1 (FOXA1) was negatively regulated by miR-338. CircHIPK3 aggravated cell injury in LPS-treated HK2 via targeting miR-338, and FOXA1 addition overturned the suppressing impacts of miR-338-3p augmentation on LPS-activated HK2 cell damage. Finally, we demonstrated that circHIPK3 modulated LPS-induced cell damage via the miR-338/FOXA1 axis.
Causality:Yes
Causal Description:Moreover, circHIPK3 interference expedited HK2 cell viability and attenuated apoptosis, inflammatory and oxidative damages following LPS stimulation.
Clinical-realted Application: