Entry Detail

General Information

Database ID: LDA0000244
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HNF1A-AS1
Full Name:HNF1A antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C12orf27|HAS1|HASTER|NCRNA00262
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):120969838End Site(bp):120972292
External Links:
Ensembl ID:ENSG00000241388
Ensembl Transcript ID:N/A
Entrez Gene:283460.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
neuroendocrine carcinoma  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1800
Disease Name:neuroendocrine carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A carcinoma that derives_from neuroendocrine cells.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
HNF1A-AS1  (Score: 0.731059)
H19  (Score: 0.731059)
HNF1A-AS1  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34037532
Disease Name:neuroendocrine carcinoma
Sample:gastric NENs tissues
Dysfunction Pattern:Expression(lower expressed)
Validated Method:Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay
Description:HNF1A-AS1 expression was decreased in gastric NENs tissues (p < 0.01). Oncostatin M was identified as the downstream target of HNF1A-AS1. Inhibition of transforming growth factor-β activity inhibited HNF1A-AS1/Oncostatin M-mediated epithelial-mesenchymal transition.
Causality:Yes
Causal Description: Over-expression of HNF1A-AS1 suppressed cellular proliferation, migration and invasion. Knockdown of transcription factor 3 inhibited the expression of HNF1A-AS1 and promoted cellular migration and invasion.
Clinical-realted Application: