Entry Detail

General Information

Database ID: LDA0000281
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LEISA
Full Name:lncRNA enhancing IL-6/STAT3 signaling activation 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LEISA|NAV2-AS6
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):19710934End Site(bp):19714672
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:100126784.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Adenocarcinoma of Lung  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33859372
Disease Name:Adenocarcinoma of Lung
Sample:LAD tissues and cells
Dysfunction Pattern:Interaction(STAT3 and IL-6 promoter)
Validated Method:In Vivo Experiment//RNA Pull-Down//Northern Blot//Western Blot//qRT-PCR//ChIP
Description:Our data showed that LEISA was highly expressed in, and correlated with the clinical progression and prognosis of LAD.Mechanistically, we demonstrated that LEISA recruited STAT3 to bind the promoter of IL-6 and upregulated IL-6 expression.
Causality:Yes
Causal Description:Ectopic expression of LEISA promoted the proliferation and suppressed apoptosis of LAD cells in vitro and in vivo.
Clinical-realted Application: