Entry Detail

General Information

Database ID: LDA0000294
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LEF1-AS1
Full Name:LEF1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LEF1NAT
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):108167525End Site(bp):108176430
External Links:
Ensembl ID:ENSG00000232021
Ensembl Transcript ID:N/A
Entrez Gene:641518.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:28   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013119
Disease Name:Spinal Cord Injuries
Category:MeSH
Type:Nervous System Diseases
Define:Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Alias:Spinal Cord Injuries//Spinal Cord Trauma//Cord Trauma, Spinal//Cord Traumas, Spinal//Spinal Cord Traumas//Trauma, Spinal Cord//Traumas, Spinal Cord//Myelopathy, Traumatic//Myelopathies, Traumatic//Traumatic Myelopathies//Traumatic Myelopathy//Injuries, Spinal Cord//Cord Injuries, Spinal//Cord Injury, Spinal//Injury, Spinal Cord//Spinal Cord Injury//Spinal Cord Transection//Cord Transection, Spinal//Cord Transections, Spinal//Spinal Cord Transections//Transection, Spinal Cord//Transections, Spinal Cord//Spinal Cord Laceration//Cord Laceration, Spinal//Cord Lacerations, Spinal//Laceration, Spinal Cord//Lacerations, Spinal Cord//Spinal Cord Lacerations//Post-Traumatic Myelopathy//Myelopathies, Post-Traumatic//Myelopathy, Post-Traumatic//Post Traumatic Myelopathy//Post-Traumatic Myelopathies//Spinal Cord Contusion//Contusion, Spinal Cord//Contusions, Spinal Cord//Cord Contusion, Spinal//Cord Contusions, Spinal//Spinal Cord Contusions

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:36
Network:
Top Causal ncRNAs:
Vof-16  (Score: 0.731059)
HECW1  (Score: 0.731059)
Hipk3  (Score: 0.731059)
LEF1-AS1  (Score: 0.731059)
LINC00158  (Score: 0.731059)
Irag2-208  (Score: 0.731059)
LncRNAAirsci  (Score: 0.731059)
CASC9  (Score: 0.731059)
PRKCSH  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33407665
Disease Name:Spinal Cord Injuries
Sample:LPS-treated SCI and microglial cells
Dysfunction Pattern:Interaction(miR-222-5p/RAMP3 )
Validated Method:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay
Description:We revealed that LncRNA LEF1-AS1 was distinctly upregulated, whereas miR-222-5p was significantly downregulated in LPS-treated SCI and microglial cells. Mechanistically, LEF1-AS1 served as a competitive endogenous RNA (ceRNA) by sponging miR-222-5p, targeting RAMP3. RAMP3 overexpression attenuated LEF1-AS1-mediated protective effects on LPS-mediated microglial cells from apoptosis and inflammation.
Causality:Yes
Causal Description:However, LEF1-AS1 knockdown enhanced cell viability, inhibited apoptosis, as well as inflammation of LPS-mediated microglial cells. On the contrary, miR-222-5p upregulation decreased cell viability, promoted apoptosis, and inflammation of microglial cells.
Clinical-realted Application: