Entry Detail


General Information

Database ID: LDA0000322
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KTN1-AS1
Full Name:KTN1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C14orf33|MYCLo-3
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):55576157End Site(bp):55580092
External Links:
Ensembl ID:ENSG00000186615
Ensembl Transcript ID:N/A
Entrez Gene:100129075.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Burkitt Lymphoma  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8584D002051
Disease Name:Burkitt lymphomaBurkitt Lymphoma
Category:Disease OntologyMeSH
Type:Infections
Define:A mature B-cell neoplasm of B-cells found in the germinal center.A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Alias:Burkitt lymphoma/leukaemia//Burkitt's Lymphoma//Burkitt's tumor//Burkitt's tumor or lymphoma//malignant lymphoma, Burkitt's type//small Non-Cleaved cell Lymphoma, Burkitt's typeBurkitt Lymphoma//Burkitt Tumor//Tumor, Burkitt//Burkitt's Tumor//Burkitts Tumor//Tumor, Burkitt's//Burkitt's Lymphoma//Burkitts Lymphoma//Lymphoma, Burkitt's//Lymphoma, Burkitt//Burkitt Leukemia//Leukemia, Burkitt//Burkitt Cell Leukemia//Leukemia, Burkitt Cell//Leukemia, Lymphocytic, L3//Lymphocytic Leukemia, L3//L3 Lymphocytic Leukemia//L3 Lymphocytic Leukemias//Leukemia, L3 Lymphocytic//Burkitt's Leukemia//Burkitts Leukemia//Leukemia, Burkitt's//Leukemia, Lymphoblastic, Burkitt-Type//African Lymphoma//Lymphoma, African

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
KTN1-AS1  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
KTN1-AS1  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:35866590
Disease Name:Burkitt Lymphoma
Sample:different types of B cell lymphoma
Dysfunction Pattern:Regulation( Myc-target genes)
Validated Method:Microarray//qRT-PCR//Western Blot
Description:We show that the top Myc-induced lncRNA KTN1-AS1 is strongly upregulated in different types of B cell lymphoma compared with their normal counterparts. Global gene expression analysis upon KTN1-AS1 depletion shows a strong enrichment of key genes in the cholesterol biosynthesis pathway as well as co-regulation of many Myc-target genes, including a moderate negative effect on the levels of Myc itself. Our study suggests a critical role for KTN1-AS1 in supporting BL cell growth by mediating co-regulation of a variety of Myc-target genes and co-activating key genes involved in cholesterol biosynthesis.
Causality:Yes
Causal Description:Knockdown of KTN1-AS1 revealed a strong negative effect on the growth of three BL cell lines.
Clinical-realted Application: