Entry Detail

General Information

Database ID: LDA0000328
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KLF3-AS1
Full Name:KLF3 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:4
Strand:-
Coordinate:
Start Site(bp):38599093End Site(bp):38664893
External Links:
Ensembl ID:ENSG00000231160
Ensembl Transcript ID:N/A
Entrez Gene:79667.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Wound Healing Assay//EdU Staining//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34745937
Disease Name:Stomach Neoplasms
Sample:gastric cancer cells
Dysfunction Pattern:Interaction(miR-223)
Validated Method:In Vivo Experiment//Wound Healing Assay//Invasion Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Description: In this study, we found that KLF3-AS1 was down-regulated in gastric cancer cells. The mechanistic studies showed that KLF3-AS1 could act as the "sponge" for miR-223 and to repress miR-223 expression in gastric cancer cells. Overexpression of miR-223 reversed the inhibitory effects of KLF3-AS1 overexpression on gastric cancer cell proliferation, invasion, migration and EMT, and attenuated the enhanced effects of KLF3-AS1 overexpression on gastric cancer cell chemosensitivity to cisplatin.
Causality:Yes
Causal Description:Overexpression of KLF3-AS1 repressed gastric cancer cell proliferation, growth. In addition, KLF3-AS1 overexpression also exerted inhibitory effects on the gastric cancer cell invasion, migration and EMT, but promoted chemosensitivity of gastric cancer cells to cisplatin.
Clinical-realted Application: