Entry Detail

General Information

Database ID: LDA0000330
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KLF3-AS1
Full Name:KLF3 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:4
Strand:-
Coordinate:
Start Site(bp):38599093End Site(bp):38664893
External Links:
Ensembl ID:ENSG00000231160
Ensembl Transcript ID:N/A
Entrez Gene:79667.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8398D010003
Disease Name:osteoarthritisOsteoarthritis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that has_material_basis_in worn out cartilage located_in joint.A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Alias:Osteoarthrosis and allied disorder//degenerative arthritis//degenerative joint disease//hypertrophic arthritis//osteoarthrosisOsteoarthritis//Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans

 

Disease Association Statistics

Total Associated ncRNA Number:784   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
MCM3AP-AS1  (Score: 0.985791)
hsa_circ_0005567  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
XIST  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qRT-PCR//Cell Viability Assay//Cell Apoptosis Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34964696
Disease Name:Osteoarthritis
Sample:chondrocytes
Dysfunction Pattern:Interaction(YBX1/PI3K/Akt/mTOR signaling pathway)
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//Cell Apoptosis Assay//Cell Viability Assay
Description:We found that MSC-Exo enhanced KLF3-AS1 expression in IL-1β-treated chondrocytes. Moreover, KLF3-AS1 interacted with YBX1 in chondrocytes. MSC-Exo-mediated KLF3-AS1 activated PI3K/Akt/mTOR signaling pathway, which was abrogated by YBX1 silencing. MSC-Exo-mediated KLF3-AS1 repressed autophagy and apoptosis of chondrocytes by activating PI3K/Akt/mTOR signaling pathway.
Causality:Yes
Causal Description:MSC-Exo-mediated KLF3-AS1 promoted cell viability and repressed apoptosis of IL-1β-treated chondrocytes. Rapamycin (autophagy activator) promoted cell viability and suppressed apoptosis of chondrocytes by activating autophagy.
Clinical-realted Application: