Entry Detail

General Information

Database ID: LDA0000337
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00240
Full Name:long intergenic non-protein coding RNA 240
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf41|NCRNA00240|bA373D17.1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):26956993End Site(bp):27023974
External Links:
Ensembl ID:ENSG00000224843
Ensembl Transcript ID:N/A
Entrez Gene:100133205.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Viability Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32526811
Disease Name:Stomach Neoplasms
Sample:GC tissues and cells
Dysfunction Pattern:regulation[ miR-124-3p / DNMT3B axis]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP
Description:Our findings suggested higher LINC00240 expression in GC tissues and cells.Then we reveal that LINC00240 acts as an oncogene in GC progression via the miR-99a-5p/IGF1R axis.
Causality:Yes
Causal Description:Through downregulating LINC00240, cell proliferation, invasion and migration were retarded in vitro, and tumorigenesis of GC cells was notably suppressed in vivo.
Clinical-realted Application:

[2] PubMed ID:34842045
Disease Name:Stomach Neoplasms
Sample:GC tissues and GC cell lines
Dysfunction Pattern:Interaction(miR-338-5p/METTL3 axis)
Validated Method:Western Blot//Bioinformatics Analysis//Migration Assay//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay
Description:We first demonstrated that LINC00240 was upregulated in GC tissues and GC cell lines. We further identified and validated the functional interaction between LINC00240 and miR-338-5p. miR-338-5p seemed to function as a downstream target negatively regulated by LINC00240, and miR-338-5p could target METTL3 at 3' UTR to downregulate its expression. In GC tissues, the expression of miR-338-5p was negatively correlated with LINC00240, and the expression of miR-338-5p was negatively correlated with METTL3.
Causality:Yes
Causal Description: In GC cell lines, the knockdown of LINC00240 inhibited GC cell proliferation and migration, but induced cell apoptosis.
Clinical-realted Application:High expression of LINC00240 was associated with advanced TNM stage, a higher extent of distant metastasis and lymph nodes metastasis, and the poor overall and disease-free survival of the patients.