Entry Detail

General Information

Database ID: LDA0000367
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00261
Full Name:long intergenic non-protein coding RNA 261
Category:LncRNA
Species:Homo sapiens
Synonyms:ALIEN|C20orf56|DEANR1|FALCOR|HCCDR1|LCAL62|NCRNA00261|TCONS_00027846|onco-lncRNA-17
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):22560553End Site(bp):22578642
External Links:
Ensembl ID:ENSG00000259974
Ensembl Transcript ID:N/A
Entrez Gene:140828.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Colonic Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Colonic Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:289D004715
Disease Name:endometriosisEndometriosis
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Alias:Endometriosis//Endometrioses//Endometrioma//Endometriomas

 

Disease Association Statistics

Total Associated ncRNA Number:46   
More Information
Causal ncRNA Number:42
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
DHRS4  (Score: 0.731059)
CCDC144NL-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31105834
Disease Name:Endometriosis
Sample:endometriosis tissues
Dysfunction Pattern:Interaction[LINC00261/miR-132-3p/BCL2L11]
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:LINC00261 was significantly downregulated in endometriosis tissues and our study indicated that it suppresses proliferation and invasion of endometriosis cells functionally in vitro. These data defined LINC00261/miR-132-3p/BCL2L11 regulatory networks may be a novel therapeutic target for endometriosis.
Causality:Yes
Causal Description:LINC00261 was significantly downregulated in endometriosis tissues and our study indicated that it suppresses proliferation and invasion of endometriosis cells functionally in vitro.
Clinical-realted Application: