Entry Detail

General Information

Database ID: LDA0000374
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LIFR-AS1
Full Name:LIFR antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):38556786End Site(bp):38671216
External Links:
Ensembl ID:ENSG00000244968
Ensembl Transcript ID:N/A
Entrez Gene:100506495.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077273
Disease Name:Thyroid Cancer, Papillary
Category:MeSH
Type:Neoplasms
Define:An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.
Alias:Thyroid Cancer, Papillary//Cancer, Papillary Thyroid//Cancers, Papillary Thyroid//Papillary Thyroid Cancer//Papillary Thyroid Cancers//Thyroid Cancers, Papillary//Thyroid Carcinoma, Papillary//Carcinoma, Papillary Thyroid//Carcinomas, Papillary Thyroid//Papillary Thyroid Carcinomas//Thyroid Carcinomas, Papillary//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Carcinoma, Nonmedullary Thyroid//Carcinomas, Nonmedullary Thyroid//Nonmedullary Thyroid Carcinomas//Thyroid Carcinoma, Nonmedullary//Thyroid Carcinomas, Nonmedullary

 

Disease Association Statistics

Total Associated ncRNA Number:340   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
BICDL3P  (Score: 0.999358)
BICDL3P  (Score: 0.999358)
hsa_circ_0000644  (Score: 0.985791)
circRAPGEF5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//qRT-PCR//ELISA//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34781815
Disease Name:Thyroid Cancer, Papillary
Sample:PTC tissues
Dysfunction Pattern:Interaction(miR-31-5p/SIDT2 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Tube Formation Assay//qRT-PCR//ELISA//Colony Formation Assay//Invasion Assay
Description:The tumor size and lymphatic metastasis were correlated with LIFR-AS1 overexpression. LIFR-AS1 and SIDT2 expressions were suppressed in PTC tissues, while that of miR-31-5p was elevated in PTC tissues.This paper demonstrates that LIFR-AS1/miR-31-5p/SIDT2 axis modulated the development of PTC.
Causality:Yes
Causal Description:Overexpressed LIFR-AS1 suppressed tumorigenesis in vivo. LIFR-AS1 was negatively correlated with miR-31-5p. LIFR-AS1 sponged miR-31-5p to upregulate SIDT2, thereby inhibiting the viability, proliferation, migration, invasion, and the secretion of vascular endothelial growth factor (VEGF) of PTC cells and angiogenesis of human umbilical vein endothelial cells (HUVECs).
Clinical-realted Application:The tumor size and lymphatic metastasis were correlated with LIFR-AS1 overexpression.