Entry Detail

General Information

Database ID: LDA0000375
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LIFR-AS1
Full Name:LIFR antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):38556786End Site(bp):38671216
External Links:
Ensembl ID:ENSG00000244968
Ensembl Transcript ID:N/A
Entrez Gene:100506495.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorPancreatic Neoplasms//Neoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:322   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
CASC2  (Score: 0.999893)
CASC2  (Score: 0.999893)
LINC00460  (Score: 0.999893)
LINC00460  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34658294
Disease Name:Pancreatic Neoplasms
Sample:PC cell lines and tumors
Dysfunction Pattern:Interaction(miRNA-150-5p/ VEGFA/Akt signaling)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description:. In this study, we determined that PC cell lines and tumors exhibit increased LIFR-AS1 expression that correlates with larger tumor size, lymph node metastasis, and more advanced TNM stage. Mechanistically, we found that METTL3 induced m6A hyper-methylation on the 3' UTR of LIFR-AS1 to enhance its mRNA stability and LIFR-AS1 could directly interact with miR-150-5p, thereby indirectly up-regulating VEGFA expressions within cells.
Causality:Yes
Causal Description: Functionally, loss-of-function studies indicated that LIFR-AS1 knockdown decreased the proliferation, migration, and invasion of PC cells in vitro.
Clinical-realted Application:. In this study, we determined that PC cell lines and tumors exhibit increased LIFR-AS1 expression that correlates with larger tumor size, lymph node metastasis, and more advanced TNM stage.