Entry Detail

General Information

Database ID: LDA0000378
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LIFR-AS1
Full Name:LIFR antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):38556786End Site(bp):38671216
External Links:
Ensembl ID:ENSG00000244968
Ensembl Transcript ID:N/A
Entrez Gene:100506495.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2394D010051
Disease Name:ovarian cancerOvarian Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the ovary.Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Alias:malignant Ovarian tumor//malignant tumour of ovary//ovarian neoplasm//ovary neoplasm//primary ovarian cancer//tumor of the OvaryOvarian Neoplasms//Neoplasm, Ovarian//Ovarian Neoplasm//Ovary Neoplasms//Neoplasm, Ovary//Neoplasms, Ovary//Ovary Neoplasm//Neoplasms, Ovarian//Ovary Cancer//Cancer, Ovary//Cancers, Ovary//Ovary Cancers//Ovarian Cancer//Cancer, Ovarian//Cancers, Ovarian//Ovarian Cancers//Cancer of Ovary//Cancer of the Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:478   
More Information
Causal ncRNA Number:418
Network:
Top Causal ncRNAs:
PVT1  (Score: 1)
ATB  (Score: 1)
GAS5  (Score: 1)
PVT1  (Score: 1)
KCNQ1OT1  (Score: 1)
ATB  (Score: 1)
XIST  (Score: 1)
SNHG3  (Score: 1)
NEAT1  (Score: 1)
KCNQ1OT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//ISH//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35778954
Disease Name:Ovarian Neoplasms
Sample:SOC patients
Dysfunction Pattern:Expression(lower expressed)
Validated Method:Western Blot//ISH//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay
Description:LIFR-AS1 was lowly expressed in SOC, which was correlated with the poor prognosis of SOC patients. LIFR-AS1 overexpression promoted the expressions of cleaved caspase-3 and E-cadherin while suppressing the malignant behaviors (proliferation, migration, and invasion) of SOC cells, the expressions of PCNA, N-cadherin, and Snail. Besides, silencing LIFR-AS1 exerted the effects opposite to overexpressed LIFR-AS1.
Causality:Yes
Causal Description: LIFR-AS1 overexpression promoted the expressions of cleaved caspase-3 and E-cadherin while suppressing the malignant behaviors (proliferation, migration, and invasion) of SOC cells, the expressions of PCNA, N-cadherin, and Snail. Besides, silencing LIFR-AS1 exerted the effects opposite to overexpressed LIFR-AS1.
Clinical-realted Application: Low expression of LIFR-AS1 in SOC was associated with the tumor size, clinical stage, lymph node metastasis, and distant metastasis.