Entry Detail

General Information

Database ID: LDA0000409
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HSD11B1-AS1
Full Name:HSD11B1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):209661359End Site(bp):209742562
External Links:
Ensembl ID:ENSG00000227591
Ensembl Transcript ID:N/A
Entrez Gene:101930114.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
skin melanoma  (Score: 0.731059)
skin melanoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8923
Disease Name:skin melanoma
Category:Disease Ontology
Type:Neoplasms
Define:A skin cancer that has_material_basis_in melanocytes.
Alias:cutaneous melanoma//malignant ear melanoma//malignant lip melanoma//malignant lower limb melanoma//malignant melanoma of ear and/or external auricular canal//malignant melanoma of skin of lower limb//malignant melanoma of skin of trunk except scrotum//malignant melanoma of skin of upper limb//malignant neck melanoma//malignant scalp melanoma//malignant trunk melanoma//malignant upper limb melanoma

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34992686
Disease Name:skin melanoma
Sample:MM tissues
Dysfunction Pattern:Expression(lower expressed)
Validated Method:Transfection//Wound Healing Assay//CCK8//qRT-PCR//RNA-seq//Colony Formation Assay//Invasion Assay//Transwell Assay
Description: Using data from The Cancer Genome Atlas database, novel lncRNA 11β-hydroxysteroid dehydrogenase type 1-antisense RNA 1 (HSD11B1-AS1) was identified, which was significantly downregulated in malignant melanoma and its downregulation was significantly associated with poor clinicopathological characteristics, including advanced T and pathological stage, Clark level, Breslow depth and ulceration and worse prognosis. Functional enrichment showed significantly enriched pathways in IFN-γ and -α response, TNF-α signaling via NF-κB and IL-2/STAT-5 and IL-6/JAK/STAT-3 signaling.
Causality:Yes
Causal Description: Moreover, cell experiments in vitro, including Cell Counting Kit-8, colony formation, wound healing and Transwell assay, suggested that overexpression of HSD11B1-AS1 significantly inhibited melanoma cell proliferation, migration and invasion.
Clinical-realted Application: Using data from The Cancer Genome Atlas database, novel lncRNA 11β-hydroxysteroid dehydrogenase type 1-antisense RNA 1 (HSD11B1-AS1) was identified, which was significantly downregulated in malignant melanoma and its downregulation was significantly associated with poor clinicopathological characteristics, including advanced T and pathological stage, Clark level, Breslow depth and ulceration and worse prognosis.