Entry Detail

General Information

Database ID: LDA0000414
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IKBKBAS
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Adenocarcinoma of Lung  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:Northern Blot//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34702815
Disease Name:Adenocarcinoma of Lung
Sample:LUAD tissues and cell lines
Dysfunction Pattern:Interaction(miR-4741/IKKβ/NF-κB.)
Validated Method:Northern Blot//Western Blot//Migration Assay//qRT-PCR//MTT//Luciferase Report Assay//Invasion Assay//Transwell Assay
Description: The upregulated IKBKBAS functioned as a competing endogenous RNA (ceRNA) via competing with IKKβ mRNA for binding miR-4741, consequently leading to upregulation and activation of IKKβ, and ultimately activation of NF-κB.
Causality:Yes
Causal Description:Herein, we reported a novel lncRNA IKBKBAS that activated NF-κB in lung adenocarcinoma (LUAD) by upregulating IKKβ, a key member of NF-κB signaling pathway, thereby promoting the metastasis of LUAD both in vitro and in vivo.
Clinical-realted Application: