Entry Detail

General Information

Database ID: LDA0000416
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IGHA1
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:ENSG00000282633
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Multiple Myeloma  (Score: 0.731059)
Multiple Myeloma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9538D009101
Disease Name:multiple myelomaMultiple Myeloma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid neoplasm that is located_in the plasma cells in bone marrow.A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Alias:Multiple Myeloma//Multiple Myelomas//Myelomas, Multiple//Myeloma, Multiple//Myeloma, Plasma-Cell//Myeloma, Plasma Cell//Myelomas, Plasma-Cell//Plasma-Cell Myeloma//Plasma-Cell Myelomas//Myelomatosis//Myelomatoses//Plasma Cell Myeloma//Cell Myeloma, Plasma//Cell Myelomas, Plasma//Myelomas, Plasma Cell//Plasma Cell Myelomas//Kahler Disease//Disease, Kahler//Myeloma-Multiple//Myeloma Multiple//Myeloma-Multiples

 

Disease Association Statistics

Total Associated ncRNA Number:180   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
CDKN2B-AS1  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
hsa_circ_0007841  (Score: 0.985791)
lnc-TCF7  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35280429
Disease Name:Multiple Myeloma
Sample:MM patient samples and cell lines
Dysfunction Pattern:Expression(highly expressed)
Validated Method:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Cell Cycle Assay//Colony Formation Assay
Description: LncRNA AL was highly expressed in MM patient samples and cell lines, and was significantly correlated with the disease stage of patients. Western blot analysis showed that knockdown of lncRNA AL significantly inhibited the expression of CDK2 and cyclin D1 and promoted the expression of cyclin suppressor p21.
Causality:Yes
Causal Description:. Knockdown of lncRNA AL significantly inhibited the proliferation and colony formation of MM cells and induced cell cycle arrest in G0/G1 phase. Knockdown of lncRNA AL significantly inhibited the proliferation of MM cells in nude mice.
Clinical-realted Application: LncRNA AL was highly expressed in MM patient samples and cell lines, and was significantly correlated with the disease stage of patients.