Entry Detail


General Information

Database ID: LDA0000427
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IL6-AS1
Full Name:IL6 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):22725395End Site(bp):22727620
External Links:
Ensembl ID:ENSG00000179428
Ensembl Transcript ID:N/A
Entrez Gene:541472.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Pulmonary Disease, Chronic Obstructive  (Score: 0.731059)
Pulmonary Disease, Chronic Obstructive  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3083D029424
Disease Name:chronic obstructive pulmonary diseasePulmonary Disease, Chronic Obstructive
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Alias:COLD//COPD//chronic obstructive airway disease//chronic obstructive lung diseasePulmonary Disease, Chronic Obstructive//Chronic Obstructive Lung Disease//Chronic Obstructive Pulmonary Diseases//COAD//COPD//Chronic Obstructive Airway Disease//Chronic Obstructive Pulmonary Disease//Airflow Obstruction, Chronic//Airflow Obstructions, Chronic//Chronic Airflow Obstructions//Chronic Airflow Obstruction

 

Disease Association Statistics

Total Associated ncRNA Number:76   
More Information
Causal ncRNA Number:26
Network:
Top Causal ncRNAs:
TUG1  (Score: 0.985791)
TUG1  (Score: 0.985791)
RUBCNL  (Score: 0.731059)
IL6-AS1  (Score: 0.731059)
GAS5  (Score: 0.731059)
MALAT1  (Score: 0.731059)
LINC00987  (Score: 0.731059)
CASC2  (Score: 0.731059)
hsa_circ_0006872  (Score: 0.731059)
circBPTF  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//ISH//Transfection//FISH//qRT-PCR//RIP//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34323408
Disease Name:Pulmonary Disease, Chronic Obstructive
Sample:patients
Dysfunction Pattern:Interaction(miR-149-5p/ IL-6)
Validated Method:RNA Pull-Down//ISH//Transfection//qRT-PCR//FISH//RIP//Luciferase Report Assay
Description:We identified a novel long noncoding RNA (lncRNA), interleukin 6 antisense RNA 1 (IL6-AS1), which is upregulated in this disease and is associated with airway inflammation. Mechanistically, cytoplasmic IL6-AS1 acts as an endogenous sponge by competitively binding to the microRNA miR-149-5p to stabilize IL-6 mRNA.
Causality:Yes
Causal Description:We found that IL6-AS1 promotes the expression of inflammatory factors, especially interleukin (IL) 6.
Clinical-realted Application: