Entry Detail

General Information

Database ID: LDA0000429
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IGF2-AS
Full Name:IGF2 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:IGF2-AS1|IGF2AS|PEG8
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):2140512End Site(bp):2148666
External Links:
Ensembl ID:ENSG00000099869
Ensembl Transcript ID:N/A
Entrez Gene:51214.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Endometriosis  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3717
Disease Name:gastric adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach carcinoma that derives_from epithelial cells of glandular origin.
Alias:adenocarcinoma of stomach//stomach adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:40   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PMS2P2  (Score: 0.731059)
ITGB1-DT  (Score: 0.731059)
FOXCUT  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
DIRC1  (Score: 0.731059)
RP1-163G9.1  (Score: 0.731059)
TM4SF1-AS1  (Score: 0.731059)
TRPM2-AS  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Wound Healing Assay//CCK8//qRT-PCR//RIP//FISH//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31183590
Disease Name:gastric adenocarcinoma
Sample:GAC tissues
Dysfunction Pattern:Interaction[sponging miR-503]
Validated Method:Wound Healing Assay//CCK8//qRT-PCR//FISH//RIP//Colony Formation Assay//Transwell Assay
Description:Our study found that lncRNA insulin growth factor 2 antisense (IGF2-AS) is up-regulated in gastric adenocarcinoma (GAC) tissues and correlated with poor prognosis in patients with GAC.Taken together, our results demonstrated that IGF2-AS takes important regulatory parts in GAC development by functioning as a ceRNA to regulate SHOX2 via sponging miR-503.
Causality:Yes
Causal Description:In vivo tumorigenicity assay showed that knockdown of IGF2-AS significantly reduced tumor volume.
Clinical-realted Application: