Entry Detail

General Information

Database ID: LDA0000433
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IQANK1
Full Name:IQ motif and ankyrin repeat containing 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CACClnc|FAM83H-AS1|FAM83HAS1|onco-lncRNA-3
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):143734139End Site(bp):143790645
External Links:
Ensembl ID:ENSG00000203499
Ensembl Transcript ID:N/A
Entrez Gene:642574.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2394D010051
Disease Name:ovarian cancerOvarian Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the ovary.Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Alias:malignant Ovarian tumor//malignant tumour of ovary//ovarian neoplasm//ovary neoplasm//primary ovarian cancer//tumor of the OvaryOvarian Neoplasms//Neoplasm, Ovarian//Ovarian Neoplasm//Ovary Neoplasms//Neoplasm, Ovary//Neoplasms, Ovary//Ovary Neoplasm//Neoplasms, Ovarian//Ovary Cancer//Cancer, Ovary//Cancers, Ovary//Ovary Cancers//Ovarian Cancer//Cancer, Ovarian//Cancers, Ovarian//Ovarian Cancers//Cancer of Ovary//Cancer of the Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:478   
More Information
Causal ncRNA Number:418
Network:
Top Causal ncRNAs:
PVT1  (Score: 1)
ATB  (Score: 1)
GAS5  (Score: 1)
PVT1  (Score: 1)
KCNQ1OT1  (Score: 1)
ATB  (Score: 1)
XIST  (Score: 1)
SNHG3  (Score: 1)
NEAT1  (Score: 1)
KCNQ1OT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//RNA Pull-Down//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:31210291
Disease Name:Ovarian Neoplasms
Sample:OC tissues,cell lines
Dysfunction Pattern:Expression[Expression[highly expressed]-expression]
Validated Method:CCK8//qRT-PCR
Description: First, qRT-PCR was used to detect the expression of lncRNA FAM83H-AS1 in OC tissues and cell lines. The results showed that lncRNA FAM83H-AS1 was significantly Expression[Expression[up-expression]-expression]-regulated in both OC tissues and OC cells when compared with normal controls.
Causality:Yes
Causal Description:The re_x0002_sults showed that Si-FAM83H-AS1 transfection significantly inhibited the expression of lncRNA FAM83H-AS1 in vitro. (Figure 3A).
Clinical-realted Application:

[2] PubMed ID:30831080
Disease Name:Ovarian Neoplasms
Sample:OC tissues,cell lines
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//RNA Pull-Down//RIP
Description:First of all, the obvious upregulation of FAM83H-AS1 was identified by qRT-PCR in OC tissues, especially in metastatic tissues, as well as in OC cell lines.
Causality:Yes
Causal Description:Through loss-of-function assays, we validated the inductive effect of FAM83H-AS1 in OC cell metastasis and radioresistance.
Clinical-realted Application:

[3] PubMed ID:33413565
Disease Name:Ovarian Neoplasms
Sample:OC tissues
Dysfunction Pattern:Epigenetics(methylation )
Validated Method:qRT-PCR
Description: Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues.
Causality:No
Causal Description:
Clinical-realted Application:High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes.