Entry Detail

General Information

Database ID: LDA0000434
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IQANK1
Full Name:IQ motif and ankyrin repeat containing 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CACClnc|FAM83H-AS1|FAM83HAS1|onco-lncRNA-3
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):143734139End Site(bp):143790645
External Links:
Ensembl ID:ENSG00000203499
Ensembl Transcript ID:N/A
Entrez Gene:642574.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11054D001749
Disease Name:urinary bladder cancerUrinary Bladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An urinary system cancer that results_in malignant growth located_in the urinary bladder.Tumors or cancer of the URINARY BLADDER.
Alias:bladder cancer//tumor of the bladderUrinary Bladder Neoplasms//Neoplasm, Urinary Bladder//Urinary Bladder Neoplasm//Bladder Tumors//Bladder Tumor//Tumor, Bladder//Tumors, Bladder//Neoplasms, Bladder//Bladder Neoplasms//Bladder Neoplasm//Neoplasm, Bladder//Urinary Bladder Cancer//Cancer, Urinary Bladder//Malignant Tumor of Urinary Bladder//Cancer of the Bladder//Bladder Cancer//Bladder Cancers//Cancer, Bladder//Cancer of Bladder

 

Disease Association Statistics

Total Associated ncRNA Number:604   
More Information
Causal ncRNA Number:428
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
TINCR  (Score: 0.999893)
PCAT6  (Score: 0.999893)
GAS5  (Score: 0.999893)
MILIP  (Score: 0.999893)
TUG1  (Score: 0.999893)
circCEP128  (Score: 0.999893)
XIST  (Score: 0.999893)
CASC9  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:IHC//Western Blot//Tunel//CCK8//qRT-PCR//Flow Cytometry//RIP//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30537032
Disease Name:Urinary Bladder Neoplasms
Sample:bladder cancer tissue, cell lines
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:In our results, the expression of FAM83H-AS1 was obviously elevated in bladder cancer tissue samples and bladder cancer cell lines compared with adjacent normal tissue samples and normal bladder epithelial cell lines, respectively.
Causality:Yes
Causal Description:The loss-of-function study showed that silencing FAM83H-AS1 expression suppressed cell proliferation, migration, and invasion and induced cycle arrest at G0/G1 phase.
Clinical-realted Application:In addition, high expression of FAM83H-AS1 was associated with advanced clinical stage and the presence of muscularis invasion and served as an independent poor prognostic factor for overall survival in patients with bladder cancer.

[2] PubMed ID:33289601
Disease Name:Urinary Bladder Neoplasms
Sample:BCa tissues,cell lines
Dysfunction Pattern:regulation[c-Myc-mediated ULK3]
Validated Method:Western Blot//Tunel//Colony Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//IHC//Transwell Assay
Description:High expression of FAM83H-AS1 was found in 82 BCa tissues and in BCa cell lines compared to the normal ones.This study evidenced that FAM83H-AS1 upregulates ULK3 expression through the transcription factor c-Myc and promotes the progression of BCa.
Causality:Yes
Causal Description:FAM83H-AS1 downregulation in T24 and BK10 cells inhibited viability, colony formation, migration, invasion, and angiogenesis of BCa cells and increased cell apoptosis.
Clinical-realted Application: