Entry Detail

General Information

Database ID: LDA0000439
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IPW
Full Name:imprinted in Prader-Willi syndrome
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00002
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):25116545End Site(bp):25122476
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:3653.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Carcinoma, Ductal  (Score: 0.731059)
Carcinoma, Ductal  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D044584
Disease Name:Carcinoma, Ductal
Category:MeSH
Type:Neoplasms
Define:Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Alias:Carcinoma, Ductal//Carcinomas, Ductal//Ductal Carcinomas//Ductal Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
IPW  (Score: 0.731059)
IPW  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//IHC//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:35078502
Disease Name:Carcinoma, Ductal
Sample:DCIS cells
Dysfunction Pattern:Interaction( IPW-miR-29c-ID2 axis)
Validated Method:In Vivo Experiment//Western Blot//Wound Healing Assay//Migration Assay//qRT-PCR//Cell Proliferation Assay//Cell Cycle Assay//IHC//ChIP
Description:We identified lncRNA IPW as a novel tumor suppressor critical for inhibiting DCIS growth.Ectopic expression of IPW in DCIS cells strongly inhibited cell proliferation, colony formation and cell cycle progression while silencing IPW in primary breast cells promoted their growth. Additionally, orthotropic implantation of cells with ectopic expression of IPW exhibited decreased tumor growth in vivo. Mechanistically, IPW epigenetically enhanced miR-29c expression by promoting H3K4me3 enrichment in its promoter region.
Causality:Yes
Causal Description:We identified lncRNA IPW as a novel tumor suppressor critical for inhibiting DCIS growth.Ectopic expression of IPW in DCIS cells strongly inhibited cell proliferation, colony formation and cell cycle progression while silencing IPW in primary breast cells promoted their growth. Additionally, orthotropic implantation of cells with ectopic expression of IPW exhibited decreased tumor growth in vivo.
Clinical-realted Application: