Entry Detail

General Information

Database ID: LDA0000446
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IGF2-AS
Full Name:IGF2 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:IGF2-AS1|IGF2AS|PEG8
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):2140512End Site(bp):2148666
External Links:
Ensembl ID:ENSG00000099869
Ensembl Transcript ID:N/A
Entrez Gene:51214.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Endometriosis  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10283D011471
Disease Name:prostate cancerProstatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A male reproductive organ cancer that is located_in the prostate.Tumors or cancer of the PROSTATE.
Alias:NGP - new growth of prostate//hereditary prostate cancer//malignant tumor of the prostate//prostate cancer, familial//prostate neoplasm//prostatic cancer//prostatic neoplasm//tumor of the prostateProstatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

 

Disease Association Statistics

Total Associated ncRNA Number:566   
More Information
Causal ncRNA Number:414
Network:
Top Causal ncRNAs:
TUG1  (Score: 1)
SNHG1  (Score: 1)
MALAT1  (Score: 1)
NORAD  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
SNHG3  (Score: 1)
MALAT1  (Score: 1)
SNHG1  (Score: 1)
NORAD  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30423304
Disease Name:Prostatic Neoplasms
Sample:Pca tissues, cell lines
Dysfunction Pattern:Regulation[ IGF2AS/IGF2 axis]
Validated Method:CCK8//qRT-PCR//Transwell Assay
Description:IGF2AS was downregulated in both PCa cell lines and human PCa tumors. IGF2 was downregulated by IGF2AS overexpression. Conversely, IGF2 upregulation revered the suppressing function of IGF2AS on PCa proliferation and invasion.
Causality:Yes
Causal Description: In VCaP and PC3 cells, lentivirus-induced IGF2AS overexpression suppressed cancer cell proliferation and invasion in vitro, and xenograft development in vivo.
Clinical-realted Application: