Entry Detail

General Information

Database ID: LDA0000447
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IGF2-AS
Full Name:IGF2 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:IGF2-AS1|IGF2AS|PEG8
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):2140512End Site(bp):2148666
External Links:
Ensembl ID:ENSG00000099869
Ensembl Transcript ID:N/A
Entrez Gene:51214.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Endometriosis  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:289D004715
Disease Name:endometriosisEndometriosis
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Alias:Endometriosis//Endometrioses//Endometrioma//Endometriomas

 

Disease Association Statistics

Total Associated ncRNA Number:46   
More Information
Causal ncRNA Number:42
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
DHRS4  (Score: 0.731059)
CCDC144NL-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//EdU Staining//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36508036
Disease Name:Endometriosis
Sample:endometriotic cells
Dysfunction Pattern:Interaction(miR-370-3p/IGF2 axis/PI3K/AKT/mTOR)
Validated Method:RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//Invasion Assay//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Description:Furthermore, insulin-like growth factor 2 antisense RNA (IGF2-AS) was uncovered to positively regulate IGF2 expression and enhanced proliferative, migratory, and invasive abilities of endometriotic cells. Mechanistically, miR-370-3p was found to bind with IGF2-AS and IGF2. IGF2-AS competitively bind with miR-370-3p to upregulate IGF2. Furthermore, IGF2-AS was revealed to activate the PI3K/AKT/mTOR signaling pathway through targeting miR-370-3p/IGF2 axis.
Causality:Yes
Causal Description:Furthermore, insulin-like growth factor 2 antisense RNA (IGF2-AS) was uncovered to positively regulate IGF2 expression and enhanced proliferative, migratory, and invasive abilities of endometriotic cells.
Clinical-realted Application: