Entry Detail

General Information

Database ID: LDA0000457
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HULC
Full Name:hepatocellular carcinoma up-regulated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HCCAT1|LINC00078|NCRNA00078
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):8652209End Site(bp):8653846
External Links:
Ensembl ID:ENSG00000285219
Ensembl Transcript ID:N/A
Entrez Gene:728655.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Liver Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:184D001859
Disease Name:bone cancerBone Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.Tumors or cancer located in bone tissue or specific BONES.
Alias:CA - bone cancer//bone neoplasm//bone tumour//malignant bone neoplasm//malignant bone tumour//malignant neoplasm of bone//malignant osseous tumor//neoplasm of bone//osseous tumorBone Neoplasms//Bone Neoplasm//Neoplasm, Bone//Neoplasms, Bone//Bone Cancer//Cancer of the Bone//Cancer of Bone

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
HULC  (Score: 0.731059)
NONRATT009773.2  (Score: 0.731059)
HULC  (Score: 0.731059)
NONRATT009773.2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30120220
Disease Name:Bone Neoplasms
Sample:neoplasm cell lines
Dysfunction Pattern:Expression[highly expressed]
Validated Method:Western Blot//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay
Description: Compared to the human normal bone cell line, we found lncRNA HULC was over-expressed in all 6 bone neoplasm cell lines, and we finally chose HT1080 and Saos-2 cell lines, which possessed the highest lncRNA HULC expression level, for the subsequent studies.
Causality:Yes
Causal Description:LncRNA HULC can promote the tumorigenesis of bone neoplasms through increasing the proliferation, invasion, and migration abilities and the expression level of EMT-related factors.
Clinical-realted Application:We then observed that the expression level of lncRNA HULC was negatively correlated with overall survival rate of bone neoplasm patients, which means that lncRNA HULC has prognostic value in patients with bone neoplasms.