Entry Detail

General Information

Database ID: LDA0000460
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HULC
Full Name:hepatocellular carcinoma up-regulated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HCCAT1|LINC00078|NCRNA00078
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):8652209End Site(bp):8653846
External Links:
Ensembl ID:ENSG00000285219
Ensembl Transcript ID:N/A
Entrez Gene:728655.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Liver Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31448453
Disease Name:lung squamous cell carcinoma
Sample:LSCC tissues
Dysfunction Pattern:Regulation[ PTPRO/NF-κB signaling pathway]
Validated Method:qRT-PCR
Description:Significantly decreased level of lncRNA HULC was observed in LSCC samples compared with adjacent tissues.Moreover, lncRNA HULC could promote the proliferation of LSCC cells by downregulating the expression PTPRO dependent on the phosphorylation and activation of nuclear factor-κB (NF-κB). The present study firstly shows strong evidence supporting a critical role of lncRNA HULC in promoting LSCC by regulating PTPRO/NF-κB signaling pathway, which provides new promising biomarkers for LSCC.
Causality:Yes
Causal Description:Moreover, lncRNA HULC could promote the proliferation of LSCC cells by downregulating the expression PTPRO dependent on the phosphorylation and activation of nuclear factor-κB (NF-κB).
Clinical-realted Application: