Entry Detail

General Information

Database ID: LDA0000478
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ICMT-DT
Full Name:ICMT divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C1orf211|LINC00337|NCRNA00337
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):6236240End Site(bp):6239444
External Links:
Ensembl ID:ENSG00000225077
Ensembl Transcript ID:N/A
Entrez Gene:148645.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34663343
Disease Name:Adenocarcinoma of Lung
Sample:lung adenocarcinoma tissues
Dysfunction Pattern:Interaction(miR-1285-3p/YTHDF1 )
Validated Method:RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay
Description: LINC00337 expression was remarkably upregulated in lung adenocarcinoma.With respect to the mechanism, LINC00337 knockdown boosted miR-1285-3p expression and then restrained YTHDF1 expression post-transcriptionally. Crucially, both miR-1285-3p decrement and YTHDF1 overexpression successfully reversed the influence on cell proliferation, migration, invasion, and apoptosis caused by LINC00337 shRNA.
Causality:Yes
Causal Description: In addition, LINC00337 knockdown was shown to repress cell migration, invasion, and proliferation, as well as the cell cycle, and gear up apoptosis in lung adenocarcinoma in vitro and in vivo.
Clinical-realted Application: