Entry Detail

General Information

Database ID: LDA0000488
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KCNQ1OT1
Full Name:KCNQ1 opposite strand/antisense transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:KCNQ1-AS2|KCNQ10T1|Kncq1|KvDMR1|KvLQT1-AS|LIT1|NCRNA00012
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):2608328End Site(bp):2699998
External Links:
Ensembl ID:ENSG00000269821
Ensembl Transcript ID:N/A
Entrez Gene:10984.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:64   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7910
Disease Name:maxillary sinus squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A squamous cell carcinoma that is located_in the maxillary sinus.
Alias:Epidermoid carcinoma of the Maxillofacial sinus

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
KCNQ1OT1  (Score: 0.731059)
KCNQ1OT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qPCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31709597
Disease Name:maxillary sinus squamous cell carcinoma
Sample:MSSCC tissues and MSSCC cell line (IMC-3)
Dysfunction Pattern:Regulation[miR-204/EphA7 axis]
Validated Method:qPCR//Luciferase Report Assay
Description:Herein, we found that KCNQ1OT1 expression was markedly upregulated in MSSCC tissues and MSSCC cell line (IMC-3) by using quantitative reverse transcription-polymerase chain reaction. Moreover, we confirmed KCNQ1OT1 could directly interact with miR-204 by bioinformatic prediction and dual luciferase assay, and miR-204 inhibitor markedly reversed MSSCC tumor phenotypes induced by shKCNQ1OT1. Finally, we demonstrated that KCNQ1OT1/miR-204 facilitated MSSCC progression by regulating Eph receptor A7 (EphA7).
Causality:Yes
Causal Description: Loss-of-function experiments revealed that the deletion of KCNQ1OT1 inhibited cell proliferation, migration, and invasion.
Clinical-realted Application: