Entry Detail

General Information

Database ID: LDA0000498
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KCNK15-AS1
Full Name:KCNK15 and WISP2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):44711862End Site(bp):44746227
External Links:
Ensembl ID:ENSG00000244558
Ensembl Transcript ID:N/A
Entrez Gene:106144538.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:31572012
Disease Name:Stomach Neoplasms
Sample:GC tissues
Dysfunction Pattern:Interaction[ KCNK15-AS1-DNMT1-MAPK and KCNK15-AS1-HDAC1-AKT]
Validated Method:qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP
Description: The expression of KCNK15-AS1 was lower in the tumor tissue compared to the normal tissue.In this study, we identified two regulatory axes, namely KCNK15-AS1-DNMT1-MAPK and KCNK15-AS1-HDAC1-AKT, which were associated with gastric cancer progression. Chidamide and 5-azacytidine might provide new modes for treating gastric cancer.
Causality:Yes
Causal Description:Both the overexpression of KCNK15-AS1 and the knockdown of the expression of miR-21 inhibited proliferation and promoted apoptosis and decreased the level of MMP-9, bcl-2, and MMP-2 but increased the level of Bax.
Clinical-realted Application: