Entry Detail

General Information

Database ID: LDA0000533
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ITCH
Full Name:itchy E3 ubiquitin protein ligase
Category:LncRNA
Species:Homo sapiens
Synonyms:ADMFD|AIF4|AIP4|NAPP1
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):34363273End Site(bp):34511773
External Links:
Ensembl ID:ENSG00000078747
Ensembl Transcript ID:N/A
Entrez Gene:83737.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Intervertebral Disc Degeneration  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:90D055959
Disease Name:degenerative disc diseaseIntervertebral Disc Degeneration
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Alias:cervical disc degenerative disease//intervertebral disc degeneration//lumbar disc degeneration//vertebral disc diseaseIntervertebral Disc Degeneration//Degeneration, Intervertebral Disc//Disc Degeneration, Intervertebral//Intervertebral Disc Degenerations//Disc Degeneration//Degeneration, Disc//Disc Degenerations//Intervertebral Disk Degeneration//Degeneration, Intervertebral Disk//Disk Degeneration, Intervertebral//Intervertebral Disk Degenerations//Disk Degeneration//Degeneration, Disk//Disk Degenerations//Disk Degradation//Degradation, Disk//Disk Degradations//Degenerative Disc Disease//Degenerative Disc Diseases//Disc Disease, Degenerative//Disc Degradation//Degradation, Disc//Disc Degradations//Degenerative Intervertebral Discs//Degenerative Intervertebral Disc//Disc, Degenerative Intervertebral//Intervertebral Disc, Degenerative//Degenerative Intervertebral Disks//Degenerative Intervertebral Disk//Disk, Degenerative Intervertebral//Intervertebral Disk, Degenerative

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
PART1  (Score: 0.731059)
RMRP  (Score: 0.731059)
circGLCE  (Score: 0.731059)
NRAD1  (Score: 0.731059)
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qPCR//CCK8//Luciferase Report Assay//Cell Apoptosis Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34015763
Disease Name:Intervertebral Disc Degeneration
Sample:IDD patients' nucleus pulposus (NP) tissues
Dysfunction Pattern:Interaction(miR-17-5p/SOX4 signaling/ Wnt/β-catenin)
Validated Method:Western Blot//qPCR//CCK8//Luciferase Report Assay//Cell Apoptosis Assay
Description:Significantly, the expression levels of circITCH were elevated in the IDD patients' nucleus pulposus (NP) tissues relative to that of normal cases. Thus, we conclude that circITCH promotes ECM degradation in IDD by activating Wnt/β-catenin through miR-17-5p/SOX4 signaling.
Causality:Yes
Causal Description:CircITCH promoted apoptosis and decreased proliferation of NP cells. CircITCH contributed to ECM degradation, as demonstrated by increased ADAMTS4 and MMP13 expression and decreased aggrecan and collagen II expression.
Clinical-realted Application: