Entry Detail

General Information

Database ID: LDA0000566
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FNDC3B
Full Name:fibronectin type III domain containing 3B
Category:LncRNA
Species:Homo sapiens
Synonyms:FAD104|PRO4979|YVTM2421
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):172039578End Site(bp):172401669
External Links:
Ensembl ID:ENSG00000075420
Ensembl Transcript ID:N/A
Entrez Gene:64778.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qPCR//RIP//PCR//IP
Weak Evidence:

 

Reference

[1] PubMed ID:30963578
Disease Name:Stomach Neoplasms
Sample: cell lines (AGS, SGC‐7901, MGC‐803, and BGC‐823)
Dysfunction Pattern:Interaction[miR‑17‑5p]
Validated Method:Western Blot//qPCR//RIP//PCR//IP
Description:We showed that circFNDC3B increased migration and invasion in gastric cancer (GC). Ectopic expression of circFNDC3B reduced the level of E‐cadherin protein to promote the epithelial–mesenchymal transition in GC. RNA immunoprecipitation assays and RNA pull‐Expression[down-expression] assays confirmed that circFNC3B increased CD44 expression, which was associated with cell adhesion, via the formation of a ternary complex of circFNDC3B‐IGF2BP3‐CD44 mRNA. These results indicated that circFNDC3B was associated with the degree of malignancy to highlight the specific characteristics of cell invasion.
Causality:Yes
Causal Description:However, Cell Counting Kit‐8 results showed that the overexpression of circFNDC3B inhibited cell proliferation, whereas silencing of circFNDC3B promoted cell proliferation (Figure S2).
Clinical-realted Application: