LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0000571
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

FLVCR1-DT

Full Name:

FLVCR1 divergent transcript

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

FLVCR1-AS1|LQK1|NCRNA00292

Chromosome:

Strand:

Coordinate:

Start Site(bp):

212856604

End Site(bp):

212858138

External Links:

Ensembl ID:	ENSG00000198468
Ensembl Transcript ID:	N/A
Entrez Gene:	642946.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

22 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Uterine Cervical Neoplasms (Score: 0.985791)

Stomach Neoplasms (Score: 0.731059)

Cholangiocarcinoma (Score: 0.731059)

Pancreatic Neoplasms (Score: 0.731059)

Glioma (Score: 0.731059)

Osteosarcoma (Score: 0.731059)

Ovarian Neoplasms (Score: 0.731059)

Colorectal Neoplasms (Score: 0.731059)

Lung Neoplasms (Score: 0.731059)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:1324	D008175
Disease Name:	lung cancer	Lung Neoplasms
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A respiratory system cancer that is located_in the lung.	Tumors or cancer of the LUNG.
Alias:		Lung Neoplasms//Pulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

Disease Association Statistics

Total Associated ncRNA Number:

344 More Information

Causal ncRNA Number:

282

Network:

Top Causal ncRNAs:

OIP5-AS1 (Score: 0.999893)

MNX1-AS1 (Score: 0.999893)

NEAT1 (Score: 0.999893)

MNX1-AS1 (Score: 0.999893)

NEAT1 (Score: 0.999893)

circHIPK3 (Score: 0.985791)

GAS5 (Score: 0.985791)

PCAT1 (Score: 0.985791)

NNT-AS1 (Score: 0.985791)

More Information

Evidence Support

Strong Evidence:	qRT-PCR
Weak Evidence:

Reference

[1] PubMed ID:	30697812
Disease Name:	Lung Neoplasms
Sample:
Dysfunction Pattern:	Regulation[ Wnt/β-catenin signaling pathway]
Validated Method:	qRT-PCR
Description:	In this study, we found that the expression of FLVCR1-AS1 was increased in lung cancer tissues according to The Cancer Genome Atlas database. Similarly, FLVCR1-AS1 was significantly upregulated in lung cancer cell lines.In sum, FLVCR1-AS1 silencing inhibited the proliferation, migration, and invasion of lung cancer cells by inhibiting the activity of the Wnt/β-catenin signaling pathway.
Causality:	Yes
Causal Description:	Knockdown of FLVCR1-AS1 dramatically reduced the cell proliferation, migration, and invasion of SPCA1 and A549.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail