Entry Detail

General Information

Database ID: LDA0000576
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FLVCR1-DT
Full Name:FLVCR1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:FLVCR1-AS1|LQK1|NCRNA00292
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):212856604End Site(bp):212858138
External Links:
Ensembl ID:ENSG00000198468
Ensembl Transcript ID:N/A
Entrez Gene:642946.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32626942
Disease Name:Glioma
Sample:GBM tissues,cell lines
Dysfunction Pattern:regulation[regulating miR-30b-3p]
Validated Method:CCK8//qRT-PCR//Transwell Assay
Description: FLVCR1?AS1 expression was significantly upregulated in GBM tissues compared with adjacent normal brain samples, and was higher in GBM cell lines compared with normal human astrocyte cells. The results from the present study demonstrated that FLVCR1‑AS1 may serve an oncogenic role in GBM and promote disease progression by interacting with miR‑30b‑3p.
Causality:Yes
Causal Description:The results from Cell Counting Kit?8 and Transwell assays confirmed that FLVCR1?AS1?knockdown inhibited GBM cell proliferation and invasion ability.
Clinical-realted Application: